Inhibition of NADPH oxidase 2 enhances resistance to viral neuroinflammation by facilitating M1-polarization of macrophages at the extraneural tissues

Inhibition of NADPH oxidase 2 enhances resistance to viral neuroinflammation by facilitating M1-polarization of macrophages at the extraneural tissues

Abstract Background Macrophages play a pivotal role in the regulation of Japanese encephalitis (JE), a severe neuroinflammation in the central nervous system (CNS) following infection with JE virus (JEV). Macrophages are known for their heterogeneity, polarizing into M1 or M2 phenotypes in the conte...

Full description

Bibliographic Details
Main Authors: Jin Young Choi, Hee Won Byeon, Seong Ok Park, Erdenebileg Uyangaa, Koanhoi Kim, Seong Kug Eo
Format: Article
Language:English
Published: BMC 2024-05-01
Series:Journal of Neuroinflammation
Subjects:
NADPH oxidase 2
Japanese encephalitis
Macrophages
Reactive oxygen species
ROS scavenger
Online Access:https://doi.org/10.1186/s12974-024-03078-8

Internet

https://doi.org/10.1186/s12974-024-03078-8

Similar Items