Fibroblast growth factor 18 alleviates stress-induced pathological cardiac hypertrophy in male mice

Fibroblast growth factor 18 alleviates stress-induced pathological cardiac hypertrophy in male mice

Although the role of FGFs in cardiovascular disease has attracted extensive attention, the potential role of FGF18 in pathological cardiac hypertrophy remains unknown. Here, the authors show the cardioprotective effect of FGF18 is mediated by maintaining redox homeostasis through FYN/Nox4 signaling.

Bibliographic Details
Main Authors: Gen Chen, Ning An, Jingling Shen, Huinan Chen, Yunjie Chen, Jia Sun, Zhicheng Hu, Junhui Qiu, Cheng Jin, Shengqu He, Lin Mei, Yanru Sui, Wanqian Li, Peng Chen, Xueqiang Guan, Maoping Chu, Yang Wang, Litai Jin, Kwonseop Kim, Xiaokun Li, Weitao Cong, Xu Wang
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-36895-1

Internet

https://doi.org/10.1038/s41467-023-36895-1

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