Induced Pluripotent Stem Cells Derived From Two Idiopathic Azoospermia Patients Display Compromised Differentiation Potential for Primordial Germ Cell Fate

Induced Pluripotent Stem Cells Derived From Two Idiopathic Azoospermia Patients Display Compromised Differentiation Potential for Primordial Germ Cell Fate

At present, the etiology of most non-obstructive azoospermia (NOA) remains unclear. In vitro generation of patient-specific induced pluripotent stem cells (iPSCs) is an effective approach for exploring the mechanisms of human disease. Here, we established iPSCs from two patients with idiopathic NOA...

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Bibliographic Details
Main Authors: Fang Fang, Zili Li, Qian Zhao, Zhen Ye, Xiuli Gu, Feng Pan, Honggang Li, Wenpei Xiang, Chengliang Xiong
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
non-obstructive azoospermia
induced pluripotent stem cells
differentiation
primordial germ cells
transcriptome analysis
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00432/full

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https://www.frontiersin.org/article/10.3389/fcell.2020.00432/full

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