Poly (I:C) and hyaluronic acid directly interact with NLRP3, resulting in the assembly of NLRP3 and ASC in a cell-free system

Poly (I:C) and hyaluronic acid directly interact with NLRP3, resulting in the assembly of NLRP3 and ASC in a cell-free system

In the NLR family, pyrin domain containing 3 (NLRP3) is an intracellular pattern recognition receptor that activates pro-caspase-1, leading to IL-1β and IL-18 processing and activation in a large complex called the NLRP3 inflammasome. Since various pathogens or endogenous metabolites have been repor...

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Bibliographic Details
Main Authors: Naoe Kaneko, Yuki Ito, Tomoyuki Iwasaki, Hiroyuki Takeda, Tatsuya Sawasaki, Kiyoshi Migita, Kazunaga Agematsu, Tomohiro Koga, Atsushi Kawakami, Akihiro Yachie, Koh-ichiro Yoshiura, Shinnosuke Morikawa, Mie Kurata, Junya Masumoto
Format: Article
Language:English
Published: SAGE Publishing 2017-08-01
Series:European Journal of Inflammation
Online Access:https://doi.org/10.1177/1721727X17711047

Internet

https://doi.org/10.1177/1721727X17711047

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