Damage-Free Shortening of Telomeres Is a Potential Strategy Supporting Blind Mole-Rat Longevity

Damage-Free Shortening of Telomeres Is a Potential Strategy Supporting Blind Mole-Rat Longevity

Telomere shortening or loss of shelterin components activates DNA damage response (DDR) pathways, leading to a replicative senescence that is usually coupled with a senescence-associated secretory phenotype (SASP). Recent studies suggested that telomere aberration that activates DDR may occur, irres...

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Bibliographic Details
Main Authors: Huda Adwan Shekhidem, Lital Sharvit, Derek M. Huffman, Irena Manov, Gil Atzmon, Imad Shams
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Genes
Subjects:
<i>Spalax</i>
shelterin
telomere length
telomerase activity
senescence
DNA damage
Online Access:https://www.mdpi.com/2073-4425/14/4/845

Internet

https://www.mdpi.com/2073-4425/14/4/845

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