Cellular senescence in the response of HR+ breast cancer to radiotherapy and CDK4/6 inhibitors

Cellular senescence in the response of HR+ breast cancer to radiotherapy and CDK4/6 inhibitors

Abstract Background Preclinical evidence from us and others demonstrates that the anticancer effects of cyclin-dependent kinase 4/6 (CDK4/6) inhibitors can be enhanced with focal radiation therapy (RT), but only when RT is delivered prior to (rather than after) CDK4/6 inhibition. Depending on tumor...

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Bibliographic Details
Main Authors: Vanessa Klapp, Aitziber Buqué, Norma Bloy, Ai Sato, Takahiro Yamazaki, Xi Kathy Zhou, Silvia C. Formenti, Lorenzo Galluzzi, Giulia Petroni
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Journal of Translational Medicine
Subjects:
β-galactosidase
INK-ATTAC mice
MCF7 cells
MDA-MB-231 cells
MPA/DMBA-driven mammary carcinogenesis
TS/A cells
Online Access:https://doi.org/10.1186/s12967-023-03964-4

Internet

https://doi.org/10.1186/s12967-023-03964-4

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