Cellular senescence in the response of HR+ breast cancer to radiotherapy and CDK4/6 inhibitors

Cellular senescence in the response of HR+ breast cancer to radiotherapy and CDK4/6 inhibitors

Abstract Background Preclinical evidence from us and others demonstrates that the anticancer effects of cyclin-dependent kinase 4/6 (CDK4/6) inhibitors can be enhanced with focal radiation therapy (RT), but only when RT is delivered prior to (rather than after) CDK4/6 inhibition. Depending on tumor...

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Bibliographic Details
Main Authors:	Vanessa Klapp, Aitziber Buqué, Norma Bloy, Ai Sato, Takahiro Yamazaki, Xi Kathy Zhou, Silvia C. Formenti, Lorenzo Galluzzi, Giulia Petroni
Format:	Article
Language:	English
Published:	BMC 2023-02-01
Series:	Journal of Translational Medicine
Subjects:	β-galactosidase INK-ATTAC mice MCF7 cells MDA-MB-231 cells MPA/DMBA-driven mammary carcinogenesis TS/A cells
Online Access:	https://doi.org/10.1186/s12967-023-03964-4

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