Neuroepithelial bodies and terminal bronchioles are niches for distinctive club cells that repair the airways following acute notch inhibition

Neuroepithelial bodies and terminal bronchioles are niches for distinctive club cells that repair the airways following acute notch inhibition

Summary: Lower airway club cells (CCs) serve the dual roles of a secretory cell and a stem cell. Here, we probe how the CC fate is regulated. We find that, in response to acute perturbation of Notch signaling, CCs adopt distinct fates. Although the vast majority transdifferentiate into multiciliated...

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Bibliographic Details
Main Authors: Sai Manoz Lingamallu, Aditya Deshpande, Neenu Joy, Kirthana Ganeshan, Neelanjana Ray, Rajesh Kumar Ladher, Makoto Mark Taketo, Daniel Lafkas, Arjun Guha
Format: Article
Language:English
Published: Elsevier 2024-09-01
Series:Cell Reports
Subjects:
CP: Developmental biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724010052

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http://www.sciencedirect.com/science/article/pii/S2211124724010052

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