Ultra-low volume intradermal administration of radiation-attenuated sporozoites with the glycolipid adjuvant 7DW8-5 completely protects mice against malaria

Ultra-low volume intradermal administration of radiation-attenuated sporozoites with the glycolipid adjuvant 7DW8-5 completely protects mice against malaria

Abstract Radiation-attenuated sporozoite (RAS) vaccines can completely prevent blood stage Plasmodium infection by inducing liver-resident memory CD8+ T cells to target parasites in the liver. Such T cells can be induced by ‘Prime-and-trap’ vaccination, which here combines DNA priming against the P....

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Bibliographic Details
Main Authors: Felicia N. Watson, Melanie J. Shears, Anya C. Kalata, Caroline J. Duncombe, A. Mariko Seilie, Chris Chavtur, Ethan Conrad, Irene Cruz Talavera, Andrew Raappana, D. Noah Sather, Sumana Chakravarty, B. Kim Lee Sim, Stephen L. Hoffman, Moriya Tsuji, Sean C. Murphy
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-53118-9

Internet

https://doi.org/10.1038/s41598-024-53118-9

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