TBK1 is ubiquitinated by TRIM5α to assemble mitophagy machinery

TBK1 is ubiquitinated by TRIM5α to assemble mitophagy machinery

Summary: Ubiquitination of mitochondrial proteins provides a basis for the downstream recruitment of mitophagy machinery, yet whether ubiquitination of the machinery itself contributes to mitophagy is unknown. Here, we show that K63-linked polyubiquitination of the key mitophagy regulator TBK1 is es...

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Bibliographic Details
Main Authors: Bhaskar Saha, Hallvard Olsvik, Geneva L. Williams, Seeun Oh, Gry Evjen, Eva Sjøttem, Michael A. Mandell
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Cell Reports
Subjects:
CP: Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724006223

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http://www.sciencedirect.com/science/article/pii/S2211124724006223

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