Targeted Delivery of HSP70 to Tumor Cells via Supramolecular Complex Based on HER2-Specific DARPin9_29 and the Barnase:Barstar Pair

Targeted Delivery of HSP70 to Tumor Cells via Supramolecular Complex Based on HER2-Specific DARPin9_29 and the Barnase:Barstar Pair

(1) Background: We have previously shown that the use of an artificial supramolecular two-component system based on chimeric recombinant proteins 4D5scFv-barnase and barstar-heat shock protein 70 KDa (HSP70) allows targeted delivery of HSP70 to the surface of tumor cells bearing HER2/neu antigen. In...

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Bibliographic Details
Main Authors: Ludmila G. Alekseeva, Olga V. Ovsyanikova, Alexey A. Schulga, Maria V. Grechikhina, Olga A. Shustova, Elena I. Kovalenko, Elena V. Svirshchevskaya, Sergey M. Deyev, Alexander M. Sapozhnikov
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Cells
Subjects:
cancer immunotherapy
tumor-targeted delivery
HSP70
DARPin9_29
HER2/neu
barnase:barstar
Online Access:https://www.mdpi.com/2073-4409/13/4/317

Internet

https://www.mdpi.com/2073-4409/13/4/317

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