Structural Aspects of LIMK Regulation and Pharmacology

Structural Aspects of LIMK Regulation and Pharmacology

Malfunction of the actin cytoskeleton is linked to numerous human diseases including neurological disorders and cancer. LIMK1 (LIM domain kinase 1) and its paralogue LIMK2 are two closely related kinases that control actin cytoskeleton dynamics. Consequently, they are potential therapeutic targets f...

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Bibliographic Details
Main Authors: Deep Chatterjee, Franziska Preuss, Verena Dederer, Stefan Knapp, Sebastian Mathea
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Cells
Subjects:
LIMK1
LIMK2
kinase
phosphorylation
small-molecule inhibitor
catalytic mechanism
Online Access:https://www.mdpi.com/2073-4409/11/1/142

Internet

https://www.mdpi.com/2073-4409/11/1/142

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