Transferrin-Decorated PLGA Nanoparticles Loaded with an Organoselenium Compound as an Innovative Approach to Sensitize MDR Tumor Cells: An In Vitro Study Using 2D and 3D Cell Models

Transferrin-Decorated PLGA Nanoparticles Loaded with an Organoselenium Compound as an Innovative Approach to Sensitize MDR Tumor Cells: An In Vitro Study Using 2D and 3D Cell Models

Multidrug resistance (MDR) is the main challenge in cancer treatment. In this sense, we designed transferrin (Tf)-conjugated PLGA nanoparticles (NPs) containing an organoselenium compound as an alternative to enhance the efficacy of cancer therapy and sensitize MDR tumor cells. Cytotoxicity studies...

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Bibliographic Details
Main Authors: Letícia Bueno Macedo, Daniele Rubert Nogueira-Librelotto, Daniela Mathes, Taís Baldissera Pieta, Micheli Mainardi Pillat, Raquel Mello da Rosa, Oscar Endrigo Dorneles Rodrigues, Maria Pilar Vinardell, Clarice Madalena Bueno Rolim
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Nanomaterials
Subjects:
selenium compound
multidrug resistance (MDR)
3D cell culture
active targeted drug delivery
in vitro antitumor activity
cell uptake
Online Access:https://www.mdpi.com/2079-4991/13/16/2306

Internet

https://www.mdpi.com/2079-4991/13/16/2306

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