Low Gut Microbial Diversity Augments Estrogen-Driven Pulmonary Fibrosis in Female-Predominant Interstitial Lung Disease

Low Gut Microbial Diversity Augments Estrogen-Driven Pulmonary Fibrosis in Female-Predominant Interstitial Lung Disease

Although profibrotic cytokines, such as IL-17A and TGF-β1, have been implicated in the pathogenesis of interstitial lung disease (ILD), the interactions between gut dysbiosis, gonadotrophic hormones and molecular mediators of profibrotic cytokine expression, such as the phosphorylation of STAT3, hav...

Full description

Bibliographic Details
Main Authors: Ozioma S. Chioma, Elizabeth Mallott, Binal Shah-Gandhi, ZaDarreyal Wiggins, Madison Langford, Andrew William Lancaster, Alexander Gelbard, Hongmei Wu, Joyce E. Johnson, Lisa Lancaster, Erin M. Wilfong, Leslie J. Crofford, Courtney G. Montgomery, Luc Van Kaer, Seth Bordenstein, Dawn C. Newcomb, Wonder Puryear Drake
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Cells
Subjects:
estrogen
gut microbiome
lung fibrosis
sarcoidosis
Th17 cells
Online Access:https://www.mdpi.com/2073-4409/12/5/766

Internet

https://www.mdpi.com/2073-4409/12/5/766

Similar Items