Value of information methods to design a clinical trial in a small population to optimise a health economic utility function

Value of information methods to design a clinical trial in a small population to optimise a health economic utility function

Abstract Background Most confirmatory randomised controlled clinical trials (RCTs) are designed with specified power, usually 80% or 90%, for a hypothesis test conducted at a given significance level, usually 2.5% for a one-sided test. Approval of the experimental treatment by regulatory agencies is...

Full description

Bibliographic Details
Main Authors: Michael Pearce, Siew Wan Hee, Jason Madan, Martin Posch, Simon Day, Frank Miller, Sarah Zohar, Nigel Stallard
Format: Article
Language:English
Published: BMC 2018-02-01
Series:BMC Medical Research Methodology
Subjects:
Decision theory
Health economics
Power
Rare disease
Regulator
Type I error
Online Access:http://link.springer.com/article/10.1186/s12874-018-0475-0

Internet

http://link.springer.com/article/10.1186/s12874-018-0475-0

Similar Items