Fenfluramine increases survival and reduces markers of neurodegeneration in a mouse model of Dravet syndrome

Fenfluramine increases survival and reduces markers of neurodegeneration in a mouse model of Dravet syndrome

Abstract Objective In patients with Dravet syndrome (DS), fenfluramine reduced convulsive seizure frequency and provided clinical benefit in nonseizure endpoints (e.g., executive function, survival). In zebrafish mutant scn1 DS models, chronic fenfluramine treatment preserved neuronal cytoarchitectu...

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Bibliographic Details
Main Authors: John Cha, Gregory Filatov, Steven J. Smith, Arnold R. Gammaitoni, Amélie Lothe, Thadd Reeder
Format: Article
Language:English
Published: Wiley 2024-02-01
Series:Epilepsia Open
Subjects:
Dravet syndrome
fenfluramine
myelin
neuroinflammation
survival
Online Access:https://doi.org/10.1002/epi4.12873

Internet

https://doi.org/10.1002/epi4.12873

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