<i>Clostridium botulinum</i> C3 Toxin for Selective Delivery of Cargo into Dendritic Cells and Macrophages

The protein toxin C3bot from <i>Clostridium botulinum</i> is a mono-ADP-ribosyltransferase that selectively intoxicates monocyte-derived cells such as macrophages, osteoclasts, and dendritic cells (DCs) by cytosolic modification of Rho-A, -B, and -C. Here, we investigated the application...

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Bibliographic Details
Main Authors: Maximilian Fellermann, Mia Stemmer, Reiner Noschka, Fanny Wondany, Stephan Fischer, Jens Michaelis, Steffen Stenger, Holger Barth
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Toxins
Subjects:
Online Access:https://www.mdpi.com/2072-6651/14/10/711