Pro-inflammatory cytokines stimulate CFTR-dependent anion secretion in pancreatic ductal epithelium

Pro-inflammatory cytokines stimulate CFTR-dependent anion secretion in pancreatic ductal epithelium

Abstract Background Loss of CFTR-dependent anion and fluid secretion in the ducts of the exocrine pancreas is thought to contribute to the development of pancreatitis, but little is known about the impact of inflammation on ductal CFTR function. Here we used adult stem cell-derived cell cultures (or...

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Bibliographic Details
Main Authors: Dora Angyal, Tessa A. Groeneweg, Anny Leung, Max Desain, Kalyan Dulla, Hugo R. de Jonge, Marcel J. C. Bijvelds
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Cellular & Molecular Biology Letters
Subjects:
CFTR
Cystic fibrosis
Cytokines
Epithelial ion transport
Organoid
Pancreatitis
Online Access:https://doi.org/10.1186/s11658-024-00537-1

Internet

https://doi.org/10.1186/s11658-024-00537-1

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