Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway

Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway

Intestinal aging is associated with declines in structure and absorption of nutrients. Here, the authors show that aging related intestinal decline is mediated by activation of the mTORC1-p38MAPK-p53 pathway in intestinal stem cells and can be ameliorated by abrogating mTORC1 or p38MAPK activity.

Bibliographic Details
Main Authors: Dan He, Hongguang Wu, Jinnan Xiang, Xinsen Ruan, Peike Peng, Yuanyuan Ruan, Ye-Guang Chen, Yibin Wang, Qiang Yu, Hongbing Zhang, Samy L. Habib, Ronald A. De Pinho, Huijuan Liu, Baojie Li
Format: Article
Language:English
Published: Nature Portfolio 2020-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13911-x

Internet

https://doi.org/10.1038/s41467-019-13911-x

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