A distinct circular DNA profile intersects with proteome changes in the genotoxic stress-related hSOD1 G93A model of ALS

A distinct circular DNA profile intersects with proteome changes in the genotoxic stress-related hSOD1 G93A model of ALS

Abstract Background Numerous genes, including SOD1, mutated in familial and sporadic amyotrophic lateral sclerosis (f/sALS) share a role in DNA damage and repair, emphasizing genome disintegration in ALS. One possible outcome of chromosomal instability and repair processes is extrachromosomal circul...

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Bibliographic Details
Main Authors: Daniela Gerovska, Julie B. Noer, Yating Qin, Quratul Ain, Donjetë Januzi, Matthias Schwab, Otto W. Witte, Marcos J. Araúzo-Bravo, Alexandra Kretz
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Cell & Bioscience
Subjects:
Amyotrophic lateral sclerosis (ALS)
ALS circulome
ALS proteome
Circular DNA
Differential analysis
DNA damage and repair
Online Access:https://doi.org/10.1186/s13578-023-01116-1

Internet

https://doi.org/10.1186/s13578-023-01116-1

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