A distinct circular DNA profile intersects with proteome changes in the genotoxic stress-related hSOD1 G93A model of ALS

Abstract Background Numerous genes, including SOD1, mutated in familial and sporadic amyotrophic lateral sclerosis (f/sALS) share a role in DNA damage and repair, emphasizing genome disintegration in ALS. One possible outcome of chromosomal instability and repair processes is extrachromosomal circul...

Full description

Bibliographic Details
Main Authors:	Daniela Gerovska, Julie B. Noer, Yating Qin, Quratul Ain, Donjetë Januzi, Matthias Schwab, Otto W. Witte, Marcos J. Araúzo-Bravo, Alexandra Kretz
Format:	Article
Language:	English
Published:	BMC 2023-09-01
Series:	Cell & Bioscience
Subjects:	Amyotrophic lateral sclerosis (ALS) ALS circulome ALS proteome Circular DNA Differential analysis DNA damage and repair
Online Access:	https://doi.org/10.1186/s13578-023-01116-1

Similar Items

Bee Venom Acupuncture Augments Anti-Inflammation in the Peripheral Organs of hSOD1G93A Transgenic Mice
by: Sun-Hwa Lee, et al.
Published: (2015-07-01)

Combined Treatment with Bojungikgi-Tang and Riluzole Regulates Muscle Metabolism and Dysfunction in the hSOD1<sup>G93A</sup> Mouse Model
by: Mudan Cai, et al.
Published: (2022-03-01)

Extrachromosomal Circular DNA (eccDNA): From Chaos to Function
by: Shanru Zuo, et al.
Published: (2022-01-01)

Tempol improves neuroinflammation and delays motor dysfunction in a mouse model (SOD1G93A) of ALS
by: Gabriela Bortolança Chiarotto, et al.
Published: (2019-11-01)

Perturbations of the Proteome and of Secreted Metabolites in Primary Astrocytes from the hSOD1(G93A) ALS Mouse Model
by: Roberto Stella, et al.
Published: (2021-06-01)

Reduced VGLUT2 expression increases motor neuron viability in Sod1G93A mice
by: Hanna Wootz, et al.
Published: (2010-01-01)

Neuroprotection by upregulation of the major histocompatibility complex class I (MHC I) in SOD1G93A mice
by: Ana Laura M. R. Tomiyama, et al.
Published: (2023-08-01)

Optimized Protocol for Proportionate CNS Cell Retrieval as a Versatile Platform for Cellular and Molecular Phenomapping in Aging and Neurodegeneration
by: Quratul Ain, et al.
Published: (2022-03-01)

Spatiotemporal evolution of pyroptosis and canonical inflammasome pathway in hSOD1G93A ALS mouse model
by: Haoyun Zhang, et al.
Published: (2022-08-01)

Analysis of Feeding Behavior Characteristics in the Cu/Zn Superoxide Dismutase 1 (SOD1) SOD1G93A Mice Model for Amyotrophic Lateral Sclerosis (ALS)
by: Yoshihiro Kitaoka, et al.
Published: (2023-03-01)

A Meta-Analysis Study of SOD1-Mutant Mouse Models of ALS to Analyse the Determinants of Disease Onset and Progression
by: Maria Ciuro, et al.
Published: (2022-12-01)

Oxidative stress and mitochondrial damage: importance in non-SOD1 ALS
by: Maria Teresa eCarri, et al.
Published: (2015-02-01)

Intravenously Administered, Retinoid Activating Nanoparticles Increase Lifespan and Reduce Neurodegeneration in the SOD1G93A Mouse Model of ALS
by: David X. Medina, et al.
Published: (2020-03-01)

Abnormal Upregulation of GPR17 Receptor Contributes to Oligodendrocyte Dysfunction in SOD1 G93A Mice
by: Elisabetta Bonfanti, et al.
Published: (2020-03-01)

Low-Input High-Molecular-Weight DNA Extraction for Long-Read Sequencing From Plants of Diverse Families
by: Alessia Russo, et al.
Published: (2022-05-01)

Effects of RAGE inhibition on the progression of the disease in hSOD1G93A ALS mice
by: Liping Liu, et al.
Published: (2020-08-01)

Secreted Metabolome of ALS-Related hSOD1(G93A) Primary Cultures of Myocytes and Implications for Myogenesis
by: Roberto Stella, et al.
Published: (2023-11-01)

Comparison of dendritic calcium transients in juvenile wild type and SOD1G93A mouse lumbar motoneurons
by: Katharina Ann Quinlan, et al.
Published: (2015-04-01)

The Effects of Bee Venom Acupuncture on the Central Nervous System and Muscle in an Animal hSOD1G93A Mutant
by: MuDan Cai, et al.
Published: (2015-03-01)

Case report: Flail leg syndrome in familial amyotrophic lateral sclerosis with L144S SOD1 mutation
by: Ewa Zapalska, et al.
Published: (2023-03-01)

GLT1 overexpression in SOD1G93A mouse cervical spinal cord does not preserve diaphragm function or extend disease
by: Ke Li, et al.
Published: (2015-06-01)

The potential benefit of leptin therapy against amyotrophic lateral sclerosis (ALS)
by: Agueda Ferrer‐Donato, et al.
Published: (2022-01-01)

Comparing therapeutic modulators of the SOD1 G93A Amyotrophic Lateral Sclerosis mouse pathophysiology
by: Albert J. B. Lee, et al.
Published: (2023-01-01)

An emerging role for misfolded wild-type SOD1 in sporadic ALS pathogenesis
by: Melissa S Rotunno, et al.
Published: (2013-12-01)

RNA Molecular Signature Profiling in PBMCs of Sporadic ALS Patients: HSP70 Overexpression Is Associated with Nuclear SOD1
by: Maria Garofalo, et al.
Published: (2022-01-01)

Neuroprotective effect of bexarotene in the SOD1G93A mouse model of amyotrophic lateral sclerosis
by: Javier eRiancho, et al.
Published: (2015-07-01)

Microglia Morphological Changes in the Motor Cortex of hSOD1<sup>G93A</sup> Transgenic ALS Mice
by: Sara Migliarini, et al.
Published: (2021-06-01)

Hemizygous Granzyme A Mice Expressing the hSOD1G93A Transgene Show Slightly Extended Lifespan
by: Laura Moreno-Martinez, et al.
Published: (2022-11-01)

Intricate and Cell Type-Specific Populations of Endogenous Circular DNA (eccDNA) in Caenorhabditis elegans and Homo sapiens
by: Massa J. Shoura, et al.
Published: (2017-10-01)

Monoaminergic control of spinal locomotor networks in SOD1G93A newborn mice
by: Léa eMilan, et al.
Published: (2014-07-01)

Accumulation of labile zinc in neurons and astrocytes in the spinal cords of G93A SOD-1 transgenic mice
by: Jean Kim, et al.
Published: (2009-05-01)

Is the expression of [-G93A(+)] human SOD1 a model to study neurodegenerations?
by: R. Stifanese, et al.
Published: (2011-01-01)

Peripheral hyperstimulation alters site of disease onset and course in SOD1 rats
by: Angelo C. Lepore, et al.
Published: (2010-09-01)

Molecular Pathology of ALS: What We Currently Know and What Important Information Is Still Missing
by: Nikol Jankovska, et al.
Published: (2021-07-01)

Peripheral administration of SOD1 aggregates does not transmit pathogenic aggregation to the CNS of SOD1 transgenic mice
by: Isil Keskin, et al.
Published: (2021-06-01)

4-Phenylbutyric Acid (4-PBA) Derivatives Prevent SOD1 Amyloid Aggregation In Vitro with No Effect on Disease Progression in SOD1-ALS Mice
by: Leenor Alfahel, et al.
Published: (2022-08-01)

Gain of interaction of ALS-linked G93A superoxide dismutase with cytosolic malate dehydrogenase
by: Yael Mali, et al.
Published: (2008-10-01)

Unraveling 50-year-old clues linking neurodegeneration and cancer to cycad toxins: are microRNAs a common mediator?
by: Peter eSpencer, et al.
Published: (2012-09-01)

Blood Level of Glial Fibrillary Acidic Protein (GFAP) Does not Correlate With Disease Progression in a Rat Model of Familial ALS (SOD1G93A Transgenic)
by: Jeremy Jeffrey, et al.
Published: (2018-11-01)

Biological Significance of microRNA Biomarkers in ALS—Innocent Bystanders or Disease Culprits?
by: Sophie Foggin, et al.
Published: (2019-06-01)