A novel pulse-chase SILAC strategy measures changes in protein decay and synthesis rates induced by perturbation of proteostasis with an Hsp90 inhibitor.

A novel pulse-chase SILAC strategy measures changes in protein decay and synthesis rates induced by perturbation of proteostasis with an Hsp90 inhibitor.

Standard proteomics methods allow the relative quantitation of levels of thousands of proteins in two or more samples. While such methods are invaluable for defining the variations in protein concentrations which follow the perturbation of a biological system, they do not offer information on the me...

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Bibliographic Details
Main Authors: Ivo Fierro-Monti, Julien Racle, Celine Hernandez, Patrice Waridel, Vassily Hatzimanikatis, Manfredo Quadroni
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3842330?pdf=render

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http://europepmc.org/articles/PMC3842330?pdf=render

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