Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG

Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG

Abstract DNA‐binding proteins, including transcription factors (TFs), play essential roles in various cellular processes and pathogenesis of diseases, deeming to be potential therapeutic targets. However, these proteins are generally considered undruggable as they lack an enzymatic catalytic site or...

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Bibliographic Details
Main Authors: Jingwei Shao, Yuqian Yan, Donglin Ding, Dejie Wang, Yundong He, Yunqian Pan, Wei Yan, Anupreet Kharbanda, Hong‐yu Li, Haojie Huang
Format: Article
Language:English
Published: Wiley 2021-10-01
Series:Advanced Science
Subjects:
cancer
oligonucleotide‐based proteolysis‐targeting chimera
protein degradation
transcription factor
Online Access:https://doi.org/10.1002/advs.202102555

Internet

https://doi.org/10.1002/advs.202102555

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