Analysis of RBP expression and binding sites identifies PTBP1 as a regulator of CD19 expression in B-ALL

Analysis of RBP expression and binding sites identifies PTBP1 as a regulator of CD19 expression in B-ALL

Despite massive improvements in the treatment of B-ALL through CART-19 immunotherapy, a large number of patients suffer a relapse due to loss of the targeted epitope. Mutations in the CD19 locus and aberrant splicing events are known to account for the absence of surface antigen. However, early mole...

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Bibliographic Details
Main Authors: Nicole Ziegler, Mariela Cortés-López, Francesca Alt, Maximilian Sprang, Arsenij Ustjanzew, Nadine Lehmann, Khalifa El Malki, Arthur Wingerter, Alexandra Russo, Olaf Beck, Sebastian Attig, Lea Roth, Julian König, Claudia Paret, Jörg Faber
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:OncoImmunology
Subjects:
CD19
B-ALL
splicing
isoforms
CART19 therapy
RBP
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2023.2184143

Internet

https://www.tandfonline.com/doi/10.1080/2162402X.2023.2184143

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