Reanalysis of a μ opioid receptor crystal structure reveals a covalent adduct with BU72

Reanalysis of a μ opioid receptor crystal structure reveals a covalent adduct with BU72

Abstract Background The first crystal structure of the active μ opioid receptor (μOR) exhibited several unexplained features. The ligand BU72 exhibited many extreme deviations from ideal geometry, along with unexplained electron density. I previously showed that inverting the benzylic configuration...

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Bibliographic Details
Main Author: Thomas A. Munro
Format: Article
Language:English
Published: BMC 2023-10-01
Series:BMC Biology
Subjects:
BU72
Covalent adduct
Crystal structure
μ opioid receptor
Revised stereochemistry
Online Access:https://doi.org/10.1186/s12915-023-01689-w

Internet

https://doi.org/10.1186/s12915-023-01689-w

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