Reanalysis of a μ opioid receptor crystal structure reveals a covalent adduct with BU72
Abstract Background The first crystal structure of the active μ opioid receptor (μOR) exhibited several unexplained features. The ligand BU72 exhibited many extreme deviations from ideal geometry, along with unexplained electron density. I previously showed that inverting the benzylic configuration...
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Format: | Article |
Language: | English |
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BMC
2023-10-01
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Series: | BMC Biology |
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Online Access: | https://doi.org/10.1186/s12915-023-01689-w |