Glutamate spillover in C. elegans triggers repetitive behavior through presynaptic activation of MGL-2/mGluR5
Katz and colleagues examine glutamate spillover effects on C. elegans behaviour. They show that impaired synaptic glutamate clearance in glial glutamate transporter mutants, causes presynaptic mgl-2/mGluR5 activation, generating postsynaptic neural activity oscillations driving repetitive behaviour.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-09581-4 |
| _version_ | 1819195251829506048 |
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| author | Menachem Katz Francis Corson Wolfgang Keil Anupriya Singhal Andrea Bae Yun Lu Yupu Liang Shai Shaham |
| author_facet | Menachem Katz Francis Corson Wolfgang Keil Anupriya Singhal Andrea Bae Yun Lu Yupu Liang Shai Shaham |
| author_sort | Menachem Katz |
| collection | DOAJ |
| description | Katz and colleagues examine glutamate spillover effects on C. elegans behaviour. They show that impaired synaptic glutamate clearance in glial glutamate transporter mutants, causes presynaptic mgl-2/mGluR5 activation, generating postsynaptic neural activity oscillations driving repetitive behaviour. |
| first_indexed | 2024-12-23T02:09:48Z |
| format | Article |
| id | doaj.art-2b7596e726bc4d719dfc4d8b1846dd17 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-23T02:09:48Z |
| publishDate | 2019-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-2b7596e726bc4d719dfc4d8b1846dd172022-12-21T18:03:49ZengNature PortfolioNature Communications2041-17232019-04-0110111310.1038/s41467-019-09581-4Glutamate spillover in C. elegans triggers repetitive behavior through presynaptic activation of MGL-2/mGluR5Menachem Katz0Francis Corson1Wolfgang Keil2Anupriya Singhal3Andrea Bae4Yun Lu5Yupu Liang6Shai Shaham7Laboratory of Developmental Genetics, The Rockefeller UniversityLaboratoire de Physique Statistique, Ecole Normale Supérieure, CNRS, Université Pierre et Marie Curie, Université Paris DiderotLaboratory of Developmental Genetics, The Rockefeller UniversityLaboratory of Developmental Genetics, The Rockefeller UniversityLaboratory of Developmental Genetics, The Rockefeller UniversityLaboratory of Developmental Genetics, The Rockefeller UniversityResearch Bioinformatics, The Rockefeller UniversityLaboratory of Developmental Genetics, The Rockefeller UniversityKatz and colleagues examine glutamate spillover effects on C. elegans behaviour. They show that impaired synaptic glutamate clearance in glial glutamate transporter mutants, causes presynaptic mgl-2/mGluR5 activation, generating postsynaptic neural activity oscillations driving repetitive behaviour.https://doi.org/10.1038/s41467-019-09581-4 |
| spellingShingle | Menachem Katz Francis Corson Wolfgang Keil Anupriya Singhal Andrea Bae Yun Lu Yupu Liang Shai Shaham Glutamate spillover in C. elegans triggers repetitive behavior through presynaptic activation of MGL-2/mGluR5 Nature Communications |
| title | Glutamate spillover in C. elegans triggers repetitive behavior through presynaptic activation of MGL-2/mGluR5 |
| title_full | Glutamate spillover in C. elegans triggers repetitive behavior through presynaptic activation of MGL-2/mGluR5 |
| title_fullStr | Glutamate spillover in C. elegans triggers repetitive behavior through presynaptic activation of MGL-2/mGluR5 |
| title_full_unstemmed | Glutamate spillover in C. elegans triggers repetitive behavior through presynaptic activation of MGL-2/mGluR5 |
| title_short | Glutamate spillover in C. elegans triggers repetitive behavior through presynaptic activation of MGL-2/mGluR5 |
| title_sort | glutamate spillover in c elegans triggers repetitive behavior through presynaptic activation of mgl 2 mglur5 |
| url | https://doi.org/10.1038/s41467-019-09581-4 |
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