Intranuclear inclusions of polyQ-expanded ATXN1 sequester RNA molecules

Intranuclear inclusions of polyQ-expanded ATXN1 sequester RNA molecules

Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant neurodegenerative disease caused by a trinucleotide (CAG) repeat expansion in the ATXN1 gene. It is characterized by the presence of polyglutamine (polyQ) intranuclear inclusion bodies (IIBs) within affected neurons. In order to investiga...

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Bibliographic Details
Main Authors: Ioannis Gkekas, Aimilia-Christina Vagiona, Nikolaos Pechlivanis, Georgia Kastrinaki, Katerina Pliatsika, Sebastian Iben, Konstantinos Xanthopoulos, Fotis E. Psomopoulos, Miguel A. Andrade-Navarro, Spyros Petrakis
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Molecular Neuroscience
Subjects:
spinocerebellar ataxia type 1
ataxin-1
intranuclear inclusion bodies
RNA sequestration
RNA-seq
protein–protein interaction network
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1280546/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2023.1280546/full

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