AAV exploits subcellular stress associated with inflammation, endoplasmic reticulum expansion, and misfolded proteins in models of cystic fibrosis.

AAV exploits subcellular stress associated with inflammation, endoplasmic reticulum expansion, and misfolded proteins in models of cystic fibrosis.

Barriers to infection act at multiple levels to prevent viruses, bacteria, and parasites from commandeering host cells for their own purposes. An intriguing hypothesis is that if a cell experiences stress, such as that elicited by inflammation, endoplasmic reticulum (ER) expansion, or misfolded prot...

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Bibliographic Details
Main Authors: Jarrod S Johnson, Martina Gentzsch, Liqun Zhang, Carla M P Ribeiro, Boris Kantor, Tal Kafri, Raymond J Pickles, R Jude Samulski
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-05-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3098238?pdf=render

Internet

http://europepmc.org/articles/PMC3098238?pdf=render

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