Ring-Fused meso-Tetraarylchlorins as Auspicious PDT Sensitizers: Synthesis, Structural Characterization, Photophysics, and Biological Evaluation

Ring-Fused meso-Tetraarylchlorins as Auspicious PDT Sensitizers: Synthesis, Structural Characterization, Photophysics, and Biological Evaluation

Novel 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-fused meso-tetraarylchlorins, with different degrees of hydrophilicity (with methyl ester, hydroxymethyl, and carboxylic acid moieties), have been synthesized and their photophysical characterization as well as in vitro photocytotoxicity assessment aga...

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Bibliographic Details
Main Authors: Mafalda Laranjo, Nelson A. M. Pereira, Andreia S. R. Oliveira, Márcia Campos Aguiar, Gonçalo Brites, Bruno F. O. Nascimento, Beatriz Serambeque, Bruna D. P. Costa, João Pina, J. Sérgio Seixas de Melo, Marta Pineiro, M. Filomena Botelho, Teresa M. V. D. Pinho e Melo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Chemistry
Subjects:
chlorins
photodynamic therapy
photosensitizer
subcellular accumulation
cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2022.873245/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2022.873245/full

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