How structural elements evolving from bacterial to human SLC6 transporters enabled new functional properties

How structural elements evolving from bacterial to human SLC6 transporters enabled new functional properties

Abstract Background Much of the structure-based mechanistic understandings of the function of SLC6A neurotransmitter transporters emerged from the study of their bacterial LeuT-fold homologs. It has become evident, however, that structural differences such as the long N- and C-termini of the eukaryo...

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Bibliographic Details
Main Authors: Asghar M. Razavi, George Khelashvili, Harel Weinstein
Format: Article
Language:English
Published: BMC 2018-03-01
Series:BMC Biology
Subjects:
Dopamine transport
SLC6 neurotransmitter transporters
Evolutionary gain of function
Molecular dynamics simulations
Markov state models
Reverse transport
Online Access:http://link.springer.com/article/10.1186/s12915-018-0495-6

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http://link.springer.com/article/10.1186/s12915-018-0495-6

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