A single amino acid residue in bank vole prion protein drives permissiveness to Nor98/atypical scrapie and the emergence of multiple strain variants.

A single amino acid residue in bank vole prion protein drives permissiveness to Nor98/atypical scrapie and the emergence of multiple strain variants.

Prions are infectious agents that replicate through the autocatalytic misfolding of the cellular prion protein (PrPC) into infectious aggregates (PrPSc) causing fatal neurodegenerative diseases in humans and animals. Prions exist as strains, which are encoded by conformational variants of PrPSc. The...

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Bibliographic Details
Main Authors: Laura Pirisinu, Michele Angelo Di Bari, Claudia D'Agostino, Ilaria Vanni, Geraldina Riccardi, Stefano Marcon, Gabriele Vaccari, Barbara Chiappini, Sylvie L Benestad, Umberto Agrimi, Romolo Nonno
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-06-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1010646

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https://doi.org/10.1371/journal.ppat.1010646

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