Protons taken hostage: Dynamic H-bond networks of the pH-sensing GPR68

Protons taken hostage: Dynamic H-bond networks of the pH-sensing GPR68

Proton-sensing G Protein Coupled Receptors (GPCRs) sense changes in the extracellular pH to effect cell signaling for cellular homeostasis. They tend to be overexpressed in solid tumors associated with acidic extracellular pH, and are of direct interest as drug targets. How proton-sensing GPCRs sens...

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Bibliographic Details
Main Authors: Bhav Kapur, Filippo Baldessari, Michalis Lazaratos, Herbert Nar, Gisela Schnapp, Alejandro Giorgetti, Ana-Nicoleta Bondar
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Proton-sensing G Protein Coupled Receptors
Protocol for structural modeling and model assessment
Graph theory
Dynamic hydrogen-bond networks
Protonation-coupled protein dynamics
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037023003094

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http://www.sciencedirect.com/science/article/pii/S2001037023003094

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