Pro-oxidant activity of indicaxanthin from Opuntia ficus indica modulates arachidonate metabolism and prostaglandin synthesis through lipid peroxide production in LPS-stimulated RAW 264.7 macrophages

Pro-oxidant activity of indicaxanthin from Opuntia ficus indica modulates arachidonate metabolism and prostaglandin synthesis through lipid peroxide production in LPS-stimulated RAW 264.7 macrophages

Macrophages come across active prostaglandin (PG) metabolism during inflammation, shunting early production of pro-inflammatory towards anti-inflammatory mediators terminating the process. This work for the first time provides evidence that a phytochemical may modulate the arachidonate (AA) metaboli...

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Bibliographic Details
Main Authors: M. Allegra, F. D’Acquisto, L. Tesoriere, A. Attanzio, M.A. Livrea
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Redox Biology
Subjects:
Indicaxanthin
Phytochemicals
Eicosanoids
Inflammation
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231714000871

Internet

http://www.sciencedirect.com/science/article/pii/S2213231714000871

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