Preparation of chitosan-coated hollow tin dioxide nanoparticles and their application in improving the oral bioavailability of febuxostat

Preparation of chitosan-coated hollow tin dioxide nanoparticles and their application in improving the oral bioavailability of febuxostat

The aim of this study was to design a chitosan-coated hollow tin dioxide nanosphere (CS-HSn) for loading febuxostat (FEB) using an adsorption method to obtain a sustained-release system (CS-HSn-FEB) to improve the oral bioavailability of FEB. The morphological characteristics of hollow tin dioxide n...

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Bibliographic Details
Main Authors: Junpeng Sun, Jiaqun Du, Xiaobang Liu, Jinyu An, Yingqiao Li, Yanan Yu, Minghui Li, Li Zheng, Chao Wu, Lili Hu
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:International Journal of Pharmaceutics: X
Subjects:
Febuxostat
Tin dioxide
Chitosan
Saturation solubility
Dissolution rate
Oral bioavailability
Online Access:http://www.sciencedirect.com/science/article/pii/S2590156723000439

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http://www.sciencedirect.com/science/article/pii/S2590156723000439

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