Cilomilast Modulates Rhinovirus-Induced Airway Epithelial ICAM-1 Expression and IL-6, CXCL8 and CCL5 Production

Cilomilast Modulates Rhinovirus-Induced Airway Epithelial ICAM-1 Expression and IL-6, CXCL8 and CCL5 Production

<b>Background:</b> Cilomilast, a phosphodiesterase-4 (PDE4) selective inhibitor, has anti-inflammatory effects in vitro and in vivo and reduces COPD exacerbations. We tested the hypothesis that cilomilast inhibits virus-induced airway epithelial intercellular adhesion molecule-1 (ICAM-1)...

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Bibliographic Details
Main Authors: Jie Zhu, Michael R. Edwards, Simon D. Message, Luminita A. Stanciu, Sebastian L. Johnston, Peter K. Jeffery
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Pharmaceuticals
Subjects:
cilomilast
PDE4 inhibitors
rhinovirus
bronchial epithelial cells
ICAM-1
IL-6
Online Access:https://www.mdpi.com/1424-8247/17/11/1554

Internet

https://www.mdpi.com/1424-8247/17/11/1554

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