Verification of Blood-Brain Barrier Disruption Based on the Clinical Validation Platform Using a Rat Model with Human Skull

Methods to improve drug delivery efficiency through blood-brain barrier disruption (BBBD) based on microbubbles and focused ultrasound (FUS) are continuously being studied. However, most studies are being conducted in preclinical trial environments using small animals. The use of the human skull sho...

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Bibliographic Details
Main Authors: Chan Yuk Park, Hyeon Seo, Eun-Hee Lee, Mun Han, Hyojin Choi, Ki-Su Park, Sang-Youl Yoon, Sung Hyun Chang, Juyoung Park
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Brain Sciences
Subjects:
Online Access:https://www.mdpi.com/2076-3425/11/11/1429