Proprotein convertase subtilisin/kexin Type 9 is required for Ahnak-mediated metastasis of melanoma into lung epithelial cells

Proprotein convertase subtilisin/kexin Type 9 is required for Ahnak-mediated metastasis of melanoma into lung epithelial cells

Previously we demonstrated that Ahnak mediates transforming growth factor-β (TGFβ)-induced epithelial-mesenchymal transition (EMT) during tumor metastasis. It is well-known that circulating tumor cells (CTCs) invade the vasculature of adjacent target tissues before working to adapt to the host envir...

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Bibliographic Details
Main Authors: Jung Min Suh, Yelin Son, Jung-Yeon Yoo, Yookyung Goh, Nabil G. Seidah, Sanghyuk Lee, Yun Soo Bae
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Ahnak
TGFβ
PCSK9
Extravasation
Metastasis
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558621000622

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http://www.sciencedirect.com/science/article/pii/S1476558621000622

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