Loss of hepatic FTCD promotes lipid accumulation and hepatocarcinogenesis by upregulating PPARγ and SREBP2

Loss of hepatic FTCD promotes lipid accumulation and hepatocarcinogenesis by upregulating PPARγ and SREBP2

Background & Aims: Exploiting key regulators responsible for hepatocarcinogenesis is of great importance for the prevention and treatment of hepatocellular carcinoma (HCC). However, the key players contributing to hepatocarcinogenesis remain poorly understood. We explored the molecular mecha...

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Bibliographic Details
Main Authors: Siying Wang, Yangyang Zhou, Ruobing Yu, Jing Ling, Botai Li, Chen Yang, Zhuoan Cheng, Ruolan Qian, Zhang Lin, Chengtao Yu, Jiaojiao Zheng, Xingling Zheng, Qi Jia, Wei Wu, Qiangxin Wu, Mengnuo Chen, Shengxian Yuan, Wei Dong, Yaoping Shi, Robin Jansen, Yujun Hao, Ming Yao, Wenxin Qin, Haojie Jin
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:JHEP Reports
Subjects:
Formimidoyltransferase cyclodeaminase
Hepatocarcinogenesis
Lipid metabolism
Tumour suppressor
Online Access:http://www.sciencedirect.com/science/article/pii/S258955592300174X

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http://www.sciencedirect.com/science/article/pii/S258955592300174X

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