Enhancing Understanding of the Visual Cycle by Applying CRISPR/Cas9 Gene Editing in Zebrafish

Enhancing Understanding of the Visual Cycle by Applying CRISPR/Cas9 Gene Editing in Zebrafish

During the vertebrate visual cycle, all-trans-retinal is exported from photoreceptors to the adjacent RPE or Müller glia wherein 11-cis-retinal is regenerated. The 11-cis chromophore is returned to photoreceptors, forming light-sensitive visual pigments with opsin GPCRs. Dysfunction of this process...

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Bibliographic Details
Main Authors: Rebecca Ward, Husvinee Sundaramurthi, Valeria Di Giacomo, Breandán N. Kennedy
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
visual cycle
inherited retinal degeneration
zebrafish
CRISPR/Cas9
CRALBP
RPE65
Online Access:http://journal.frontiersin.org/article/10.3389/fcell.2018.00037/full

Internet

http://journal.frontiersin.org/article/10.3389/fcell.2018.00037/full

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