Sirtuin-1 Activation Controls Tumor Growth by Impeding Th17 Differentiation via STAT3 Deacetylation

Sirtuin-1 Activation Controls Tumor Growth by Impeding Th17 Differentiation via STAT3 Deacetylation

Sirtuin-1 deacetylates proteins and has emerged as a critical regulator of different cellular processes, particularly inflammation. Basal SIRT1 activity was previously found to limit Th9 and enhance Th17 differentiation in mice, but the effect of pharmacological SIRT1 activation on T cell differenti...

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Bibliographic Details
Main Authors: Emeric Limagne, Marion Thibaudin, Romain Euvrard, Hélène Berger, Pauline Chalons, Frédérique Végan, Etienne Humblin, Romain Boidot, Cédric Rébé, Valentin Derangère, Sylvain Ladoire, Lionel Apetoh, Dominique Delmas, François Ghiringhelli
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:Cell Reports
Subjects:
SIRT1
Th17
STAT3
RORγt
cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717304631

Internet

http://www.sciencedirect.com/science/article/pii/S2211124717304631

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