Reference-guided de novo assembly approach improves genome reconstruction for related species
Abstract Background The development of next-generation sequencing has made it possible to sequence whole genomes at a relatively low cost. However, de novo genome assemblies remain challenging due to short read length, missing data, repetitive regions, polymorphisms and sequencing errors. As more an...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2017-11-01
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| Series: | BMC Bioinformatics |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12859-017-1911-6 |