A cost-effective sequencing method for genetic studies combining high-depth whole exome and low-depth whole genome

A cost-effective sequencing method for genetic studies combining high-depth whole exome and low-depth whole genome

Abstract Whole genome sequencing (WGS) at high-depth (30X) allows the accurate discovery of variants in the coding and non-coding DNA regions and helps elucidate the genetic underpinnings of human health and diseases. Yet, due to the prohibitive cost of high-depth WGS, most large-scale genetic assoc...

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Bibliographic Details
Main Authors: Claude Bhérer, Robert Eveleigh, Katerina Trajanoska, Janick St-Cyr, Antoine Paccard, Praveen Nadukkalam Ravindran, Elizabeth Caron, Nimara Bader Asbah, Peyton McClelland, Clare Wei, Iris Baumgartner, Marc Schindewolf, Yvonne Döring, Danielle Perley, François Lefebvre, Pierre Lepage, Mathieu Bourgey, Guillaume Bourque, Jiannis Ragoussis, Vincent Mooser, Daniel Taliun
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:npj Genomic Medicine
Online Access:https://doi.org/10.1038/s41525-024-00390-3

Internet

https://doi.org/10.1038/s41525-024-00390-3

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