Testing the Role of Glutamate NMDA Receptors in Peripheral Trigeminal Nociception Implicated in Migraine Pain

Testing the Role of Glutamate NMDA Receptors in Peripheral Trigeminal Nociception Implicated in Migraine Pain

The pro-nociceptive role of glutamate in the CNS in migraine pathophysiology is well established. Glutamate, released from trigeminal afferents, activates second order nociceptive neurons in the brainstem. However, the function of peripheral glutamate receptors in the trigeminovascular system sugges...

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Bibliographic Details
Main Authors: Cindy Guerrero-Toro, Kseniia Koroleva, Elizaveta Ermakova, Oleg Gafurov, Polina Abushik, Pasi Tavi, Guzel Sitdikova, Rashid Giniatullin
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
glutamate
migraine
NMDA
CGRP
trigeminal ganglia
trigeminal nerve
Online Access:https://www.mdpi.com/1422-0067/23/3/1529

Internet

https://www.mdpi.com/1422-0067/23/3/1529

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