Using ELP Repeats as a Scaffold for De Novo Construction of Gadolinium-Binding Domains within Multifunctional Recombinant Proteins for Targeted Delivery of Gadolinium to Tumour Cells

Using ELP Repeats as a Scaffold for De Novo Construction of Gadolinium-Binding Domains within Multifunctional Recombinant Proteins for Targeted Delivery of Gadolinium to Tumour Cells

Three artificial proteins that bind the gadolinium ion (Gd<sup>3+</sup>) with tumour-specific ligands were de novo engineered and tested as candidate drugs for binary radiotherapy (BRT) and contrast agents for magnetic resonance imaging (MRI). Gd<sup>3+</sup>-binding modules...

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Bibliographic Details
Main Authors: Natalia V. Pozdniakova, Oxana V. Ryabaya, Alevtina S. Semkina, Vsevolod A. Skribitsky, Alexei B. Shevelev
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
recombinant protein engineering
ELP
binary radiotherapy
gadolinium contrast agent
F3 peptide
RGD
Online Access:https://www.mdpi.com/1422-0067/23/6/3297

Internet

https://www.mdpi.com/1422-0067/23/6/3297

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