Rat Pharmacokinetics and In Vitro Metabolite Identification of KM-819, a Parkinson’s Disease Candidate, Using LC-MS/MS and LC-HRMS

Rat Pharmacokinetics and In Vitro Metabolite Identification of KM-819, a Parkinson’s Disease Candidate, Using LC-MS/MS and LC-HRMS

FAF1 (FAS-associated factor 1) is involved in the activation of Fas cell surface death receptors and plays a role in apoptosis and necrosis. In patients with Parkinson’s disease, FAF1 is overexpressed in dopaminergic neurons in the substantia nigra. KM-819, an FAF1 inhibitor, has shown potential for...

Full description

Bibliographic Details
Main Authors: Hae-In Choi, Taeheon Kim, Jin Woo Kim, Gi Ju Lee, Jinyoung Choi, Yoon-Jee Chae, Eunhee Kim, Tae-Sung Koo
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Molecules
Subjects:
KM-819
FAF1 inhibitor
LC-MS/MS
LC-HRMS
pharmacokinetics
metabolite identification
Online Access:https://www.mdpi.com/1420-3049/29/5/1004

Internet

https://www.mdpi.com/1420-3049/29/5/1004

Similar Items