Bi-functionalized aminoguanidine-PEGylated periodic mesoporous organosilica nanoparticles: a promising nanocarrier for delivery of Cas9-sgRNA ribonucleoproteine

Bi-functionalized aminoguanidine-PEGylated periodic mesoporous organosilica nanoparticles: a promising nanocarrier for delivery of Cas9-sgRNA ribonucleoproteine

Abstract Background There is a great interest in the efficient intracellular delivery of Cas9-sgRNA ribonucleoprotein complex (RNP) and its possible applications for in vivo CRISPR-based gene editing. In this study, a nanoporous mediated gene-editing approach has been successfully performed using a...

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Bibliographic Details
Main Authors: Pardis Rahimi Salekdeh, Leila Ma’mani, Javad Tavakkoly-Bazzaz, Hossein Mousavi, Mohammad Hossein Modarressi, Ghasem Hosseini Salekdeh
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Journal of Nanobiotechnology
Subjects:
Aminoguanidine Functionalized
Bi-functionalized Periodic Mesoporous Organosilica Nanoparticles
Cas9-sgRNA Ribonucleoproteine
Delivery nano-system
Gene editing
PEGylated
Online Access:https://doi.org/10.1186/s12951-021-00838-z

Internet

https://doi.org/10.1186/s12951-021-00838-z

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