Localization of RNAi Machinery to Axonal Branch Points and Growth Cones Is Facilitated by Mitochondria and Is Disrupted in ALS

Localization of RNAi Machinery to Axonal Branch Points and Growth Cones Is Facilitated by Mitochondria and Is Disrupted in ALS

Local protein synthesis in neuronal axons plays an important role in essential spatiotemporal signaling processes; however, the molecular basis for the post-transcriptional regulation controlling this process in axons is still not fully understood. Here we studied the axonal mechanisms underlying th...

Full description

Bibliographic Details
Main Authors: Noga Gershoni-Emek, Topaz Altman, Ariel Ionescu, Christopher J. Costa, Tal Gradus-Pery, Dianna E. Willis, Eran Perlson
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
axonal transport
microRNA
mitochondria
RISC
ALS
Dicer
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00311/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2018.00311/full

Similar Items