The difficulty in translating the preclinical success of combined TGFβ and immune checkpoint inhibition to clinical trial

Summary: Immune checkpoint inhibitors (ICIs) have transformed the treatment paradigm for solid tumors. However, even in cancers generally considered ICI-sensitive, responses can vary significantly. Thus, there is an ever-increasing interest in identifying novel means of improving therapeutic respons...

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Bibliographic Details
Main Authors: Anastasia E. Metropulos, Hidayatullah G. Munshi, Daniel R. Principe
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:EBioMedicine
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S235239642200562X