Tanshinone I induces cell apoptosis by reactive oxygen species-mediated endoplasmic reticulum stress and by suppressing p53/DRAM-mediated autophagy in human hepatocellular carcinoma

Tanshinone I induces cell apoptosis by reactive oxygen species-mediated endoplasmic reticulum stress and by suppressing p53/DRAM-mediated autophagy in human hepatocellular carcinoma

Human hepatocellular carcinoma (HCC) is the most common type of liver cancer, and it has a high mortality rate. Despite surgical treatments, radiotherapy, and chemotherapy, the median survival of patients with advanced HCC is low. Evidence has shown that tanshinone (TA) I exhibits anti-proliferative...

Full description

Bibliographic Details
Main Authors: Xu Liu, JiKui Liu
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Artificial Cells, Nanomedicine, and Biotechnology
Subjects:
Hepatocellular carcinoma (HCC)
apoptosis
cell cycle arrest
reactive oxygen species (ROS)
autophagy
p53/DRAM
Online Access:https://www.tandfonline.com/doi/10.1080/21691401.2019.1709862

Internet

https://www.tandfonline.com/doi/10.1080/21691401.2019.1709862

Similar Items